Alyssa Plaud Mainelli, MSN, APRN, PMHNP-BC
Psychiatric-Mental Health Nurse Practitioner
Medication Management & Psychotherapy
Treating the Whole Person, Not Just the Diagnosis
Alyssa Plaud Mainelli is a board-certified Psychiatric-Mental Health Nurse Practitioner who believes that you are a human first - not an illness, not a diagnosis, not a label. She brings a holistic, trauma-informed approach to psychiatric care, taking time to understand the many aspects of your life that have shaped the feelings and experiences you are managing today.
Alyssa specializes in working with adolescents and adults living with ADHD, anxiety, depression, and OCD, and she is a strong believer that psychotherapy and medication management go hand in hand in promoting true wellness.
What Alyssa Treats
ADHD
Comprehensive evaluation and treatment combining medication management with psychotherapy for adolescents and adults navigating ADHD.
Anxiety
Helping individuals understand and manage anxiety through a holistic, personalized approach that addresses root causes, not just symptoms.
Depression
Collaborative treatment for depression that combines therapy and medication support, building a sustainable path toward wellness.
OCD
Evidence-based psychiatric care for OCD, integrating medication management with therapeutic strategies tailored to your experience.
Trauma
Trauma-informed care that considers not just your symptoms but the broader context of your life, helping you make sense of what you are feeling.
Clinical Background
🎓 Regis College
Master of Science in Nursing, Psychiatric-Mental Health Nurse Practitioner
Graduate specialty, 2025🎓 Northeastern University
Accelerated Bachelor of Science in Nursing (ABSN)
Accelerated program, 2021🎓 UMass Boston
Bachelor of Science in Biology
Scientific foundation, 2018🏧 Inpatient Psychiatry
Clinical experience in inpatient psychiatric settings managing complex presentations with calm, compassionate precision
High-acuity psychiatric care💙 Oncology Nursing
Experience in oncology care connecting with individuals during some of the most challenging moments of their lives
Compassionate, thorough careA Holistic, Trauma-Informed Approach
The Whole Person
Alyssa takes the time to look at the whole person - your history, your daily life, your goals, and the experiences that have brought you to where you are now. She provides trauma-informed care that considers not just your symptoms but the broader context of your life, helping you make sense of what you are feeling and build a path forward that is grounded and sustainable.
Psychotherapy + Medication
What sets Alyssa apart is her commitment to combining psychotherapy with medication management. She does not believe in simply prescribing and moving on. Instead, she works with you to build a comprehensive treatment plan where therapy and medication support each other, giving you the best possible foundation for lasting change.
A Unique Perspective
Alyssa's unique educational path - rooted in both the biological sciences and advanced psychiatric nursing - gives her a well-rounded perspective on the connection between mind, body, and overall health. Her clinical background across high-acuity environments has shaped her ability to remain calm under pressure, manage complex clinical presentations, and connect with individuals during some of the most challenging moments of their lives.
Looking Ahead
Alyssa is passionate about creating a space where her clients feel seen, heard, and understood as whole people. She is dedicated to providing compassionate, evidence-based psychiatric care that empowers you to move forward with clarity, confidence, and a stronger sense of who you are.
Ready to Get Started?
Alyssa is currently accepting new clients for telehealth appointments. Submit an intake request or contact our office to learn more.