Alyssa Plaud Mainelli MSN, APRN, PMHNP-BC
Psychiatric nurse practitioner for children, adolescents and adults, ages 10 and up. ADHD, anxiety, depression and OCD. Holistic, trauma-informed, and human first.
Duxbury, in person, and telehealth across Massachusetts
Treating the Whole Person, Not Just the Diagnosis
Alyssa Plaud Mainelli is a board-certified psychiatric mental health nurse practitioner who believes that you are a human first: not an illness, not a diagnosis, not a label. She brings a holistic, trauma-informed approach to psychiatric care, taking the time to understand the many aspects of your life that have shaped the feelings and experiences you are managing today.
Alyssa works with children, adolescents and adults from age 10, living with ADHD, anxiety, depression and OCD. She is a strong believer that psychotherapy and medication management go hand in hand, and she builds treatment plans where the two support each other rather than running in parallel.
Her path into psychiatry runs through the biological sciences, an accelerated nursing degree, and clinical work in inpatient psychiatry and oncology. That background shaped two things patients notice quickly: she stays calm with complex presentations, and she connects with people during some of the hardest moments of their lives without rushing them.
For patients under 18, parents and guardians are part of the conversation from the first visit, so the plan is one the whole household can support. Alyssa is passionate about creating a space where her patients feel seen, heard and understood as whole people, and about care that helps them move forward with clarity, confidence and a stronger sense of who they are.
You are a human first. Not an illness, not a diagnosis, not a label. I take the time to understand the many aspects of your life that have shaped the feelings and experiences you are managing today.
Alyssa Plaud Mainelli, MSN, APRN, PMHNP-BC
What Alyssa Treats
Choose one to read how she approaches it.
ADHD
Comprehensive evaluation and treatment that combines medication management with psychotherapy, for children from age 10, adolescents and adults. The plan is built around how ADHD actually shows up in a school day or a working week, with parents part of the picture for younger patients.
Anxiety
A holistic, personalized approach to anxiety that addresses root causes rather than symptoms alone, with precise medication choices where they help and the therapy to make the gains hold.
Depression
Collaborative treatment that combines therapy and medication support, building a sustainable path toward wellness. Scores are tracked at every visit, and the plan changes when the scores do.
OCD
Evidence-based psychiatric care for obsessive-compulsive disorder, integrating medication management with therapeutic strategies tailored to your experience and your age.
Trauma
Trauma-informed care that considers not just your symptoms but the broader context of your life, helping you make sense of what you are feeling and build a path forward that is grounded and sustainable.
Who Alyssa Works Best With
Fit matters. Here is an honest read on both sides of it.
Alyssa is probably a good fit if you
- Are the parent of a child or teen, age 10 or older, and want a prescriber who takes the time to understand the whole kid
- Are an adult who wants therapy and medication from the same clinician, in one plan
- Want your history and the context of your life treated as relevant, not just the symptom list
- Are living with OCD and want medication and therapeutic strategies integrated rather than offered separately
- Want to be seen in person on the South Shore, or by video when a school day or a working calendar does not leave room for the drive
- Want a clinician who stays calm with complexity and explains things clearly
Alyssa may not be the right match if you
- Have a child under 10
- Want therapy only, without a prescriber. Sarah Carey, Maria Martinez Calderon and Joe Giallombardo are the people to ask for
- Are in acute crisis and need stabilization rather than outpatient care
Not sure? Our intake team will match you with the right clinician on the team, even if it is not Alyssa.
A Holistic, Trauma-Informed Approach
The Whole Person
Alyssa takes the time to look at the whole person: your history, your daily life, your goals, and the experiences that brought you to where you are now. Trauma-informed care considers the broader context of your life, not just your symptoms, so the path forward is grounded and sustainable.
Psychotherapy and Medication, Together
What sets Alyssa apart is her commitment to combining psychotherapy with medication management. She does not believe in prescribing and moving on. She works with you to build a comprehensive plan where therapy and medication support each other.
A Scientific Foundation
A path rooted in the biological sciences and advanced psychiatric nursing gives Alyssa a well-rounded perspective on the connection between mind, body and overall health. Her clinical background in high-acuity settings shaped her ability to stay calm under pressure and manage complex presentations.
Families, for Younger Patients
For children and teens, parents and guardians are part of the plan from the first visit: what is happening, what the plan is, and what support at home looks like, explained in plain language.
From First Contact to a Plan
Most new patients are seen within two weeks.
Request an intake
Online, in about two minutes, or by phone at (781) 803-7757. Parents and guardians can complete the intake on behalf of a minor.
We verify your benefits
Our team reaches out within two business days and checks your insurance before your first visit, so there are no surprises afterward.
The evaluation
Your first visit, in Duxbury or by video, is a structured assessment, not a quick prescription visit: history, context and the measures we will track from here.
A plan you helped write
You leave with a plan, a timeline and the measures we will track. Every follow-up starts with the score and with what actually happened in your week.
Clinical Background
Duxbury and a Screen
Same evaluation, same measures, same clinician, wherever you are seen. Children from age 10, teens and adults.
Ready When You Are
Alyssa is accepting new patients, ages 10 and up, in person at our Duxbury office and by telehealth across Massachusetts. Booking online takes about two minutes, benefits are verified before your first visit, and most new patients are seen within two weeks.